The Church of Panagia Parigoritissa (Ναός της Παναγίας της Παρηγορήτισσας) is the most important Byzantine-era church in Arta. It was built around 1290 by the despot of Epirus Nikephoros I Komnenos Doukas (1271-1296), his wife, and their son. It served as the katholikon of a monastery. It is a two story structure with a central dome and four smaller domes. A mosaic of Christ Pantokrator is in the central dome.