Seleukeia (Seleucia ad Calycadnum, modern Silifke) was a coastal city of Cilicia and Isauria. As ecclesiastical metropolis, Seleukeia was the site of a synod that discussed Arianism in 359. Seleukeia was headquarters of a civil governor and a military commander, comes Isauriae. It was an active port and the site of an imperial factory that manufactured cloth for the army and officials. Local conditions are revealed in the miracles of St. Thekla, whose shrine lay outside Seleukeia. In 616 Heraclius established a mint at Seleukeia during his campaigns against the Persians; its transfer to Isauria in 617 suggests that Seleukeia was taken. Seleukeia was seat of the droungarios of the Kibyrrhaiotai theme, then capital of the theme of Seleukeia. After a temporary loss to the Turks, Seleukeia was recovered and refortified in 1099. It had a prosperous Jewish community in the mid-12th century and was the base for Manuel I's temporary reconquest of Cilicia in 1159. It fell to the Armenians soon after 1180. Seleukeia contains ruins of a church converted from a temple and a fortress with some Byzantine walls.
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Oxford Dictionary of Byzantium